解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The DNMT1 cytosine methyltransferase enzyme contains a large ∼300-aa intrinsically disordered domain (IDD) that we previously showed regulated DNA methylation patterns in mouse ES cells. Here we generated seven mouse lines with different mutations in the IDD. Homozygous mutant mice of five lines developed normally, wi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.173609
更新日期:2015-02-01 00:00:00
abstract::A leucine, leucyl-tRNA synthetase-dependent pathway activates TorC1 kinase and its downstream stimulation of protein synthesis, a major nitrogen consumer. We previously demonstrated, however, that control of Gln3, a transcription activator of catabolic genes whose products generate the nitrogenous precursors for prote...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.173831
更新日期:2015-02-01 00:00:00
abstract::The application of quantitative genetics in plant and animal breeding has largely focused on additive models, which may also capture dominance and epistatic effects. Partitioning genetic variance into its additive and nonadditive components using pedigree-based models (P-genomic best linear unbiased predictor) (P-BLUP...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.171322
更新日期:2014-12-01 00:00:00
abstract::Hybrid incompatibility can result from gene misregulation produced by divergence in trans-acting regulatory factors and their cis-regulatory targets. However, change in trans-acting factors may be constrained by pleiotropy, which would in turn limit the evolution of incompatibility. We employed a mechanistically expli...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.171397
更新日期:2014-12-01 00:00:00
abstract::Type III galactosemia is a metabolic disorder caused by reduced activity of UDP-galactose-4-epimerase, which participates in galactose metabolism and the generation of various UDP-sugar species. We characterized gale-1 in Caenorhabditis elegans and found that a complete loss-of-function mutation is lethal, as has been...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.170084
更新日期:2014-12-01 00:00:00
abstract::Restriction site-associated DNA sequencing or genotyping-by-sequencing (GBS) approaches allow for rapid and cost-effective discovery and genotyping of thousands of single-nucleotide polymorphisms (SNPs) in multiple individuals. However, rigorous quality control practices are needed to avoid high levels of error and bi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.169052
更新日期:2014-11-01 00:00:00
abstract::Timely spindle disassembly is essential for coordination of mitotic exit with cytokinesis. In the budding yeast Saccharomyces cerevisiae, the microtubule-associated protein She1 functions in one of at least three parallel pathways that promote spindle disassembly. She1 phosphorylation by the Aurora kinase Ipl1 facilit...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163238
更新日期:2014-11-01 00:00:00
abstract::Rare genetic variants have recently been studied for genome-wide associations with human complex diseases. Existing rare variant methods are based on the hypothesis-testing framework that predefined variant sets need to be tested separately. The power of those methods is contingent upon accurate selection of variants ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.167403
更新日期:2014-11-01 00:00:00
abstract::We use three allopatric populations of the stalk-eyed fly Teleopsis dalmanni from Southeast Asia to test two predictions made by the sex chromosome drive hypothesis for Haldane's rule. The first is that modifiers that suppress or enhance drive should evolve rapidly and independently in isolated populations. The second...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.167536
更新日期:2014-11-01 00:00:00
abstract::Adaptation from de novo mutation can produce so-called soft selective sweeps, where adaptive alleles of independent mutational origin sweep through the population at the same time. Population genetic theory predicts that such soft sweeps should be likely if the product of the population size and the mutation rate towa...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.165571
更新日期:2014-10-01 00:00:00
abstract::In multicellular organisms, genetic programs guide cells to adopt cell fates as tissues are formed during development, maintained in adults, and repaired after injury. Here we explore how a small molecule in the environment can switch a genetic program from one fate to another. Wild-type Caenorhabditis elegans XX adul...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.169409
更新日期:2014-10-01 00:00:00
abstract::MiRNAs bear an increasing number of functions throughout development and in the aging adult. Here we address their role in establishing sexually dimorphic traits and sexual identity in male and female Drosophila. Our survey of miRNA populations in each sex identifies sets of miRNAs differentially expressed in male and...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.169268
更新日期:2014-10-01 00:00:00
abstract::For multiallelic loci, standard measures of linkage disequilibrium provide an incomplete description of the correlation of variation at two loci, especially when there are different numbers of alleles at the two loci. We have developed a complementary pair of conditional asymmetric linkage disequilibrium (ALD) measure...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.165266
更新日期:2014-09-01 00:00:00
abstract::Substantial intrastrain variation at the nucleotide level complicates molecular and genetic studies in zebrafish, such as the use of CRISPRs or morpholinos to inactivate genes. In the absence of robust inbred zebrafish lines, we generated NHGRI-1, a healthy and fecund strain derived from founder parents we sequenced t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.166769
更新日期:2014-09-01 00:00:00
abstract::Phytochromes play an important role in light signaling and photoperiodic control of flowering time in plants. Here we propose that the red/far-red light photoreceptor HvPHYTOCHROME C (HvPHYC), carrying a mutation in a conserved region of the GAF domain, is a candidate underlying the early maturity 5 locus in barley (H...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.165613
更新日期:2014-09-01 00:00:00
abstract::The Collaborative Cross (CC) was designed to facilitate rapid gene mapping and consists of hundreds of recombinant inbred lines descended from eight diverse inbred founder strains. A decade in production, it can now be applied to mapping projects. Here, we provide a proof of principle for rapid identification of major...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163014
更新日期:2014-09-01 00:00:00
abstract::Telomeric DNA repeats are key features of chromosomes that allow the maintenance of integrity and stability in the telomeres. However, interstitial telomere sites (ITSs) can also be found along the chromosomes, especially near the centromere, where they may appear following chromosomal rearrangements like Robertsonian...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.166421
更新日期:2014-08-01 00:00:00
abstract::Paramecium has long been a model eukaryote. The sequence of the Paramecium tetraurelia genome reveals a history of three successive whole-genome duplications (WGDs), and the sequences of P. biaurelia and P. sexaurelia suggest that these WGDs are shared by all members of the aurelia species complex. Here, we present th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163287
更新日期:2014-08-01 00:00:00
abstract::Directional export of messenger RNA (mRNA) protein particles (mRNPs) through nuclear pore complexes (NPCs) requires multiple factors. In Saccharomyces cerevisiae, the NPC proteins Nup159 and Nup42 are asymmetrically localized to the cytoplasmic face and have distinct functional domains: a phenylalanine-glycine (FG) re...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.164012
更新日期:2014-08-01 00:00:00
abstract::This article focuses on conducting global testing for association between a binary trait and a set of rare variants (RVs), although its application can be much broader to other types of traits, common variants (CVs), and gene set or pathway analysis. We show that many of the existing tests have deteriorating performan...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.165035
更新日期:2014-08-01 00:00:00
abstract::Maize (Zea mays L.) serves as model plant for heterosis research and is the crop where hybrid breeding was pioneered. We analyzed genomic and phenotypic data of 1254 hybrids of a typical maize hybrid breeding program based on the important Dent × Flint heterotic pattern. Our main objectives were to investigate genome ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.165860
更新日期:2014-08-01 00:00:00
abstract::Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected under neutral evolution and described statistically by Kingman's...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.160986
更新日期:2014-07-01 00:00:00
abstract::The RNA polymerase II (Pol-II) holoenzyme, responsible for messenger RNA production, typically consists of 10-12 subunits. Our laboratory previously demonstrated that maternally deposited, long, noncoding, template RNAs are essential for programmed genome rearrangements in the ciliate Oxytricha trifallax. Here we show...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163279
更新日期:2014-07-01 00:00:00
abstract::To identify novel genomic regions that regulate sex determination, we utilized the powerful C57BL/6J-Y(POS) (B6-Y(POS)) model of XY sex reversal where mice with autosomes from the B6 strain and a Y chromosome from a wild-derived strain, Mus domesticus poschiavinus (Y(POS)), show complete sex reversal. In B6-Y(POS), th...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.160259
更新日期:2014-07-01 00:00:00
abstract::During segmentation of vertebrate embryos, somites form in accordance with a periodic pattern established by the segmentation clock. In the zebrafish (Danio rerio), the segmentation clock includes six hairy/enhancer of split-related (her/hes) genes, five of which oscillate due to negative autofeedback. The nonoscillat...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163642
更新日期:2014-06-01 00:00:00
abstract::Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.114.163105
更新日期:2014-06-01 00:00:00
abstract::X chromosome inactivation (XCI) is an epigenetic process that almost completely inactivates one of two X chromosomes in somatic cells of mammalian females. A few genes are known to escape XCI and the mechanism for this escape remains unclear. Here, using mouse trophoblast stem (TS) cells, we address whether particular...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.162800
更新日期:2014-06-01 00:00:00
abstract::Evolutionary forces shape patterns of genetic diversity within populations and contribute to phenotypic variation. In particular, recurrent positive selection has attracted significant interest in both theoretical and empirical studies. However, most existing theoretical models of recurrent positive selection cannot e...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.156935
更新日期:2014-05-01 00:00:00
abstract::We develop a maximum penalized-likelihood (MPL) method to estimate the fitnesses of amino acids and the distribution of selection coefficients (S = 2Ns) in protein-coding genes from phylogenetic data. This improves on a previous maximum-likelihood method. Various penalty functions are used to penalize extreme estimate...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.162263
更新日期:2014-05-01 00:00:00
abstract::The neutral rate of allelic substitution is analyzed for a class-structured population subject to a stationary stochastic demographic process. The substitution rate is shown to be generally equal to the effective mutation rate, and under overlapping generations it can be expressed as the effective mutation rate in new...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163345
更新日期:2014-05-01 00:00:00
abstract::Since the publication of the first comprehensive linkage map for the laboratory mouse, the architecture of recombination as a basic biological process has become amenable to investigation in mammalian model organisms. Here we take advantage of high-density genotyping and the unique pedigree structure of the incipient ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.161653
更新日期:2014-05-01 00:00:00
abstract::Bisphenol A (BPA) is an organic compound to which human populations are ubiquitously exposed. Epidemiological data suggest BPA exposure might be associated with higher rates of diabetes and reproductive anomalies. Health concerns also include transgenerational consequences, but these mechanisms are crudely defined. Si...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.163170
更新日期:2014-05-01 00:00:00
abstract::Studying phage codon adaptation is important not only for understanding the process of translation elongation, but also for reengineering phages for medical and industrial purposes. To evaluate the effect of mutation and selection on phage codon usage, we developed an index to measure selection imposed by host transla...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.162842
更新日期:2014-05-01 00:00:00
abstract::The bristle worm Platynereis dumerilii displays many interesting biological characteristics. These include its reproductive timing, which is synchronized to the moon phase, its regenerative capacity that is hormonally controlled, and a slow rate of evolution, which permits analyses of ancestral genes and cell types. A...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.112.148254
更新日期:2014-05-01 00:00:00
abstract::Pseudo-homothallism is a reproductive strategy elected by some fungi producing heterokaryotic sexual spores containing genetically different but sexually compatible nuclei. This lifestyle appears as a compromise between true homothallism (self-fertility with predominant inbreeding) and complete heterothallism (with ex...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.159988
更新日期:2014-05-01 00:00:00
abstract::Drosophila melanogaster, an ancestrally African species, has recently spread throughout the world, associated with human activity. The species has served as the focus of many studies investigating local adaptation relating to latitudinal variation in non-African populations, especially those from the United States and...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.161463
更新日期:2014-05-01 00:00:00
abstract::Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.158824
更新日期:2014-04-01 00:00:00
abstract::Chromosomal double-strand breaks (DSBs) that have only one end with homology to a donor duplex undergo repair by strand invasion followed by replication to the chromosome terminus (break-induced replication, BIR). Using a transformation-based assay system, it was previously shown that BIR could occur by several rounds...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.162297
更新日期:2014-04-01 00:00:00
abstract::The involvement of Schizosaccharomyces pombe prm1(+) in cell fusion during mating and its relationship with other genes required for this process have been addressed. S. pombe prm1Δ mutant exhibits an almost complete blockade in cell fusion and an abnormal distribution of the plasma membrane and cell wall in the area ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.159558
更新日期:2014-04-01 00:00:00
abstract::In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.160705
更新日期:2014-04-01 00:00:00